Highly oxygenated stigmastane-type steroids from the aerial parts of Vernonia anthelmintica Willd.
Steroids
; 77(7): 811-8, 2012 Jun.
Article
en En
| MEDLINE
| ID: mdl-22445686
ABSTRACT
Nine new highly oxygenated stigmastane-type steroids, vernoanthelcin A-I (1-9), and two new stigmastane-type steroidal glycosides, vernoantheloside A and B (10 and 11) were isolated from the aerial parts of Vernonia anthelmintica Willd. The structures of compounds 1-11 were determined on the basis of IR, MS, 1D-NMR, and 2D-NMR, and their absolute configurations were deduced using single-crystal X-ray diffraction and the CD exciton chirality method. Compounds 1, 5, 7, 9 and 10 were tested for their effects on estrogen biosynthesis in human ovarian granulosa-like cells (KGN cells).
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1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Esteroides
/
Asteraceae
Idioma:
En
Revista:
Steroids
Año:
2012
Tipo del documento:
Article