Lymph node homing of T cells and dendritic cells via afferent lymphatics.
Trends Immunol
; 33(6): 271-80, 2012 Jun.
Article
en En
| MEDLINE
| ID: mdl-22459312
ABSTRACT
The continuous migration of immune cells is of utmost importance for the induction of both protective immunity as well as immunological tolerance. However, relatively little is known about the molecular cues that regulate the entry of immune cells from peripheral, nonlymphoid tissues into afferent lymph vessels and, in particular, their subsequent transmigration from afferent lymphatics into the parenchyma of draining lymph nodes (LNs). Here, we review the requirements for T cells and dendritic cells (DCs) to enter initial afferent lymph vessels of the skin. We discuss how these cells subsequently gain access to the paracortex of draining lymph nodes; a location that allows for efficient interaction between both cell populations, providing the right environment for the induction of immunity as well as tolerance.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Linfocitos T
/
Movimiento Celular
/
Ganglios Linfáticos
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Trends Immunol
Asunto de la revista:
ALERGIA E IMUNOLOGIA
Año:
2012
Tipo del documento:
Article
País de afiliación:
Alemania