Deletion of UL21 causes a delay in the early stages of the herpes simplex virus 1 replication cycle.
J Virol
; 86(12): 7003-7, 2012 Jun.
Article
en En
| MEDLINE
| ID: mdl-22496211
ABSTRACT
The herpes simplex virus 1 (HSV-1) U(L)21 gene encodes a 62-kDa tegument protein with homologs in the alpha-, beta-, and gammaherpesvirus subfamilies. In the present study, we characterized a novel U(L)21-null virus and its genetic repair to determine whether this protein plays a role in early stages of the HSV-1 replication cycle. Single-step growth analyses, protein synthesis time courses, and mRNA quantifications indicated that the absence of U(L)21 results in a delay early in the HSV-1 replication cycle.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Proteínas Virales
/
Replicación Viral
/
Regulación hacia Abajo
/
Eliminación de Gen
/
Herpesvirus Humano 1
/
Herpes Simple
Tipo de estudio:
Etiology_studies
Límite:
Humans
Idioma:
En
Revista:
J Virol
Año:
2012
Tipo del documento:
Article
País de afiliación:
Estados Unidos