Mouse model for efficacy testing of antituberculosis agents via intrapulmonary delivery.
Antimicrob Agents Chemother
; 56(7): 3957-9, 2012 Jul.
Article
en En
| MEDLINE
| ID: mdl-22547626
Here we describe an experimental murine model that allows for aerosolized antituberculosis drug efficacy testing. Intrapulmonary aerosol delivery of isoniazid, capreomycin, and amikacin to mice with pulmonary infection of Mycobacterium tuberculosis demonstrated efficacy in reducing pulmonary bacterial loads similar to that seen by standard drug delivery methods, even when lower concentrations of drugs and fewer doses were used in the aerosolized drug regimens. Interestingly, intrapulmonary delivery of isoniazid also reduced the bacterial load in the spleen.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Tuberculosis Pulmonar
/
Isoniazida
/
Pulmón
/
Antituberculosos
Límite:
Animals
Idioma:
En
Revista:
Antimicrob Agents Chemother
Año:
2012
Tipo del documento:
Article
País de afiliación:
Estados Unidos