[Chemoradiotherapy for anal squamous cell carcinoma].
Gan To Kagaku Ryoho
; 39(5): 713-7, 2012 May.
Article
en Ja
| MEDLINE
| ID: mdl-22584321
ABSTRACT
In the guidelines on American National Comprehensive Cancer Network, local excision with adequate margin is recommended as a primary treatment for patients with T1, N0, and well-differentiated anal margin cancers. Otherwise, concurrent chemotherapy using mitomycin C(10mg/m², day 1 and 29)and 5-FU(1,000mg/m2/day, continuous intravenous infusion, day 1-4 and 29-32)with radiation(total dose of 45-59 Gy)is the recommended primary treatment for all other stages of nonmetastatic anal margin and anal canal cancer. Abdominoperineal resection is performed for patients with local recurrent diseases or residual tumor after chemoradiotherapy. Chemotherapy, using cisplatin(100mg/m², day 2)and 5-FU(1,000mg/m²/day, day 1-5)every four weeks, is recommended for patients with distant metastases, and radiotherapy can also be given for the local control of symptomatic anal lesions. Abdominoperineal resection has been performed in Japan; however, use of chemoradiotherapy is expected to increase for patients with anal squamous cell carcinoma. Clarification of the correct positioning of chemoradiotherapy using cisplatin, and the development of treatment using oral anticancer agents, are expected in the future by a clinical trial now in progress.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Neoplasias del Ano
/
Carcinoma de Células Escamosas
/
Quimioradioterapia
Tipo de estudio:
Clinical_trials
/
Guideline
Límite:
Humans
Idioma:
Ja
Revista:
Gan To Kagaku Ryoho
Año:
2012
Tipo del documento:
Article
País de afiliación:
Japón