Bioactive briarane diterpenoids from the South China Sea gorgonian Dichotella gemmacea.
Bioorg Med Chem Lett
; 22(13): 4368-72, 2012 Jul 01.
Article
en En
| MEDLINE
| ID: mdl-22647719
ABSTRACT
Six new briarane diterpenoids, gemmacolides T-Y (1-6), were isolated together with three known analogs, juncenolide J (7), praelolide (8), and junceellolide C (9), from the South China Sea gorgonian Dichotella gemmacea. The structures of the new compounds were elucidated by detailed spectroscopic analysis and comparison with reported data. The absolute configuration was suggested based on biosynthetic considerations. In an in vitro bioassay, compounds 3 and 6 showed potent growth inhibition towards tumor cell lines of A549 and MG63, being stronger than the positive control of adriamycin. These compounds also exhibited weak antimicrobial activity against the bacterium Escherichia coli and the fungi Microbotryum violaceum and Septoria tritici.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Antozoos
/
Diterpenos
/
Compuestos Heterocíclicos de 4 o más Anillos
/
Antiinfecciosos
Límite:
Animals
/
Humans
País/Región como asunto:
Asia
Idioma:
En
Revista:
Bioorg Med Chem Lett
Asunto de la revista:
BIOQUIMICA
/
QUIMICA
Año:
2012
Tipo del documento:
Article