Lasionectrin, a naphthopyrone from a Lasionectria sp.
J Nat Prod
; 75(6): 1228-30, 2012 Jun 22.
Article
en En
| MEDLINE
| ID: mdl-22694295
ABSTRACT
A new naphthopyrone derivative, lasionectrin (1), was isolated from fermentations of an Acremonium-like fungus provisionally identified as a Lasionectria sp. (Ascomycota, Hypocreales) and isolated from forest leaf litter from Equatorial Guinea. Its structure was determined by a combination of spectroscopic techniques, including UV, (+)-HRESIMS, and 1D and 2D NMR spectroscopy, and comparison with published data for related fungal metabolites. Compound 1 inhibited the growth of Plasmodium falciparum with an IC(50) value of 11 µM.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Pironas
/
Hypocreales
/
Naftalenos
/
Antimaláricos
Límite:
Humans
País/Región como asunto:
Africa
Idioma:
En
Revista:
J Nat Prod
Año:
2012
Tipo del documento:
Article
País de afiliación:
España