[Characteristic of microglial activation of hippocampus in experimental epileptic rats].
Zhejiang Da Xue Xue Bao Yi Xue Ban
; 41(3): 310-4, 2012 05.
Article
en Zh
| MEDLINE
| ID: mdl-22723167
ABSTRACT
OBJECTIVE:
To investigate the characteristics of microglial activation of hippocampus in experimental epileptic rats.METHODS:
Morphological changes and proliferation of OX-42 positive cells were compared at different time points after status of epilepticus (SE) in lithium-pilocarpine induced epileptic rats.RESULTS:
OX-42 positive cells were activated after SE, which increased to a peak at 3-7 d and in a relatively stable state at 7-14 d; then gradually decreased after 14d and returned to slightly higher level than previously at 21 d.CONCLUSION:
Inflammatory injury, microglial activation and cell proliferation are closely related after seizures, microglial activation may be an important mechanism in the inflammatory injury of epilepsy.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Estado Epiléptico
/
Microglía
Tipo de estudio:
Prognostic_studies
Límite:
Animals
Idioma:
Zh
Revista:
Zhejiang Da Xue Xue Bao Yi Xue Ban
Asunto de la revista:
MEDICINA
Año:
2012
Tipo del documento:
Article
País de afiliación:
China