ABO and RhD blood groups and gestational hypertensive disorders: a population-based cohort study.
BJOG
; 119(10): 1232-7, 2012 Sep.
Article
en En
| MEDLINE
| ID: mdl-22734590
ABSTRACT
OBJECTIVE:
To examine the association between ABO and RhD blood groups and gestational hypertensive disorders in a large population-based cohort.DESIGN:
Cohort study. Risks of gestational hypertensive disorders, pre-eclampsia, and severe pre-eclampsia, estimated by odds ratios for maternal ABO blood group and RhD status.SETTING:
National health registers of Sweden. POPULATION All singleton deliveries in Sweden born to first-time mothers during the period 1987-2002 [total n = 641 926; any gestational hypertensive disorders, n = 39 011 (6.1%); pre-eclampsia cases, n = 29 337 (4.6%); severe pre-eclampsia cases, n = 8477 (1.3%)].METHODS:
Using blood group O as a reference, odds ratios of gestational hypertensive disorders, pre-eclampsia, and severe pre-eclampsia were obtained from logistic regression models adjusted for potential confounding factors. MAIN OUTCOMEMEASURES:
Gestational hypertensive disorders, pre-eclampsia, and severe pre-eclampsia.RESULTS:
Compared with blood group O, all non-O blood groups had modest but statistically significantly higher odds of pre-eclampsia. Blood group AB had the highest risk for pre-eclampsia (OR = 1.10, 95% CI 1.04-1.16) and severe pre-eclampsia (OR = 1.18, 95% CI 1.07-1.30). RhD-positive mothers had a small increased risk for pre-eclampsia (OR = 1.07, 95% CI 1.03-1.10).CONCLUSIONS:
In the largest study on this topic to date, women with AB blood group have the highest risks of gestational hypertensive disorders, pre-eclampsia, and severe pre-eclampsia, whereas women with O blood group have the lowest risks of developing these disorders. Although the magnitude of increased risk is small, this finding may help improve our understanding of the etiology of pre-eclampsia.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Preeclampsia
/
Sistema del Grupo Sanguíneo Rh-Hr
/
Sistema del Grupo Sanguíneo ABO
/
Hipertensión Inducida en el Embarazo
Tipo de estudio:
Etiology_studies
/
Incidence_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Límite:
Adult
/
Female
/
Humans
/
Pregnancy
País/Región como asunto:
Europa
Idioma:
En
Revista:
BJOG
Asunto de la revista:
GINECOLOGIA
/
OBSTETRICIA
Año:
2012
Tipo del documento:
Article
País de afiliación:
Estados Unidos