The centriolar satellite protein Cep131 is important for genome stability.
J Cell Sci
; 125(Pt 20): 4770-9, 2012 Oct 15.
Article
en En
| MEDLINE
| ID: mdl-22797915
ABSTRACT
The centrosome acts as a centre for microtubule organisation and plays crucial roles in cell polarity, migration, growth and division. Cep131 has recently been described as a basal body component essential for cilium formation, but its function in non-ciliogenic cells is unknown. We identified human Cep131 (also known as AZI1) in a screen for regulators of genome stability. We show that centrosomal localisation of Cep131 is cell-cycle-regulated and requires both an intact microtubule network and a functional dynein-dynactin transport system. Cep131 is recruited to centriolar satellites by PCM1, and localised to the centriolar core region by both pericentrin and Cep290. Depletion of Cep131 results in a reduction in proliferation rate, centriole amplification, an increased frequency of multipolar mitosis, chromosomal instability and an increase in post-mitotic DNA damage. These data therefore highlight the importance of human Cep131 for maintaining genomic integrity.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Centriolos
/
Centrosoma
/
Proteínas de Ciclo Celular
/
Inestabilidad Genómica
/
Proteínas de Microtúbulos
Límite:
Humans
Idioma:
En
Revista:
J Cell Sci
Año:
2012
Tipo del documento:
Article
País de afiliación:
Reino Unido