Chikungunya-induced cell death is limited by ER and oxidative stress-induced autophagy.
Autophagy
; 8(8): 1261-3, 2012 Aug.
Article
en En
| MEDLINE
| ID: mdl-22836517
ABSTRACT
It has been recognized that macroautophagy constitutes an important survival mechanism that allows both the maintenance of cellular homeostasis and the regulation of programmed cell death pathways (e.g., apoptosis). Although several pathogens have been described to induce autophagy, the prosurvival function of this process in infectious models remains poorly characterized. Our recent studies on chikungunya virus (CHIKV), the causative agent of major epidemics in India, Southeast Asia and southern Europe, reveal a novel mechanism by which autophagy limits the cytopathic effects of CHIKV by impinging upon virus-induced cell death pathways.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Autofagia
/
Virus Chikungunya
/
Estrés Oxidativo
/
Estrés del Retículo Endoplásmico
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Autophagy
Año:
2012
Tipo del documento:
Article
País de afiliación:
Francia