Effect of a contralateral lesion on neurological recovery from stroke in rats.
Restor Neurol Neurosci
; 30(6): 491-5, 2012.
Article
en En
| MEDLINE
| ID: mdl-22868223
ABSTRACT
PURPOSE:
Clinical studies suggest a correlation between changes in activity of the contralesional cerebral cortex and spontaneous recovery from stroke, but whether this is a causal relationship is uncertain.METHODS:
Young adult Sprague-Dawley male rats underwent unilateral or bilateral permanent distal middle cerebral artery occlusion (dMCAO). Infarct volume was determined by 2,3,5-triphenyltetrazolium chloride (TTC) staining 24 hr after dMCAO, and functional outcome was assessed 1-28 days after dMCAO using the ladder rung walking and limb placing tests.RESULTS:
Infarct volume was unchanged, but functional neurological deficits were reduced 1 day after bilateral compared to unilateral dMCAO.CONCLUSIONS:
Activity in the contralesional cerebral cortex may inhibit functional motor recovery after experimental stroke.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Infarto Cerebral
/
Recuperación de la Función
/
Infarto de la Arteria Cerebral Media
/
Lateralidad Funcional
Límite:
Animals
Idioma:
En
Revista:
Restor Neurol Neurosci
Asunto de la revista:
NEUROLOGIA
Año:
2012
Tipo del documento:
Article
País de afiliación:
Estados Unidos