Mitochondrial biogenesis and fragmentation as regulators of protein degradation in striated muscles.
J Mol Cell Cardiol
; 55: 64-72, 2013 Feb.
Article
en En
| MEDLINE
| ID: mdl-22902321
ABSTRACT
Mitochondria are dynamic organelles which adapt their morphology by fusion and fission events to the bioenergetic requirements of the cell. Cardiac and skeletal muscles are tissues with high energy demand and mitochondrial plasticity plays a key role in the homeostasis of these cells. Indeed, alterations in mitochondrial morphology, distribution and function are common features in catabolic conditions. Moreover, dysregulation of mitochondrial dynamics affects the signaling pathways that regulate muscle mass. This review discusses the recent findings of the role of mitochondrial fusion/fission and mitophagy in the control of proteolytic pathways. This article is part of a special issue entitled "Focus on Cardiac Metabolism".
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Músculo Estriado
/
Mitocondrias Musculares
Límite:
Animals
/
Humans
Idioma:
En
Revista:
J Mol Cell Cardiol
Año:
2013
Tipo del documento:
Article
País de afiliación:
Italia