Biogenesis and mechanism of action of small non-coding RNAs: insights from the point of view of structural biology.
Int J Mol Sci
; 13(8): 10268-10295, 2012.
Article
en En
| MEDLINE
| ID: mdl-22949860
ABSTRACT
Non-coding RNAs are dominant in the genomic output of the higher organisms being not simply occasional transcripts with idiosyncratic functions, but constituting an extensive regulatory network. Among all the species of non-coding RNAs, small non-coding RNAs (miRNAs, siRNAs and piRNAs) have been shown to be in the core of the regulatory machinery of all the genomic output in eukaryotic cells. Small non-coding RNAs are produced by several pathways containing specialized enzymes that process RNA transcripts. The mechanism of action of these molecules is also ensured by a group of effector proteins that are commonly engaged within high molecular weight protein-RNA complexes. In the last decade, the contribution of structural biology has been essential to the dissection of the molecular mechanisms involved in the biosynthesis and function of small non-coding RNAs.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Genoma
/
ARN Pequeño no Traducido
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Int J Mol Sci
Año:
2012
Tipo del documento:
Article
País de afiliación:
Portugal