Biomarkers of brain damage in preterm infants.
J Matern Fetal Neonatal Med
; 25 Suppl 4: 101-4, 2012 Oct.
Article
en En
| MEDLINE
| ID: mdl-22958034
ABSTRACT
OBJECTIVE:
There is growing evidence on the usefulness of biomarkers in the early detection of preterm infants at risk for brain damage. However, among different tools Activin A, S100B protein and adrenomedullin assessment offer the possibility to investigate brain/multiorgan function and development. This could be especially useful in perinatal medicine that requires even more non-invasive techniques in order to fulfill the minimal handling in diagnostic and therapeutic strategy performance. MATERIALS ANDMETHODS:
The concept of Unconventional Biological Fluid (UBF urine and saliva) is becoming even stronger and regards the assessment in non-invasive biological fluids of biochemical markers involved in the cascade of events leading to brain damage.RESULTS:
Activin A, S100B protein and adrenomedullin in UBF were increased in preterm newborns developing brain damage and/or ominous outcome.CONCLUSIONS:
The present manuscript offers an update on the usefulness of Activin A, S100B protein an adrenomedullin in UBF as brain damage markers. The findings open a new cue on the use of these markers in daily neonatal intensive care unit (NICU) activities.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Lesiones Encefálicas
/
Recien Nacido Prematuro
/
Biomarcadores
/
Enfermedades del Prematuro
Tipo de estudio:
Screening_studies
Límite:
Humans
/
Newborn
Idioma:
En
Revista:
J Matern Fetal Neonatal Med
Asunto de la revista:
OBSTETRICIA
/
PERINATOLOGIA
Año:
2012
Tipo del documento:
Article
País de afiliación:
Italia