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The G protein-coupled taste receptor T1R1/T1R3 regulates mTORC1 and autophagy.
Wauson, Eric M; Zaganjor, Elma; Lee, A-Young; Guerra, Marcy L; Ghosh, Anwesha B; Bookout, Angie L; Chambers, Chris P; Jivan, Arif; McGlynn, Kathleen; Hutchison, Michele R; Deberardinis, Ralph J; Cobb, Melanie H.
Afiliación
  • Wauson EM; Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, Dallas, TX 75390-9041, USA.
Mol Cell ; 47(6): 851-62, 2012 Sep 28.
Article en En | MEDLINE | ID: mdl-22959271
ABSTRACT
Cells continually assess their energy and nutrient state to maintain growth and survival and engage necessary homeostatic mechanisms. Cell-autonomous responses to the fed state require the surveillance of the availability of amino acids and other nutrients. The mammalian target of rapamycin complex 1 (mTORC1) integrates information on nutrient and amino acid availability to support protein synthesis and cell growth. We identify the G protein-coupled receptor (GPCR) T1R1/T1R3 as a direct sensor of the fed state and amino acid availability. Knocking down this receptor, which is found in most tissues, reduces the ability of amino acids to signal to mTORC1. Interfering with this receptor alters localization of mTORC1, downregulates expression of pathway inhibitors, upregulates key amino acid transporters, blocks translation initiation, and induces autophagy. These findings reveal a mechanism for communicating amino acid availability through a GPCR to mTORC1 in mammals.
Asunto(s)

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Autofagia / Proteínas / Receptores Acoplados a Proteínas G / Células Secretoras de Insulina Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Mol Cell Asunto de la revista: BIOLOGIA MOLECULAR Año: 2012 Tipo del documento: Article País de afiliación: Estados Unidos

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Autofagia / Proteínas / Receptores Acoplados a Proteínas G / Células Secretoras de Insulina Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Mol Cell Asunto de la revista: BIOLOGIA MOLECULAR Año: 2012 Tipo del documento: Article País de afiliación: Estados Unidos