Selective RNA versus DNA G-quadruplex targeting by inâ
situ click chemistry.
Angew Chem Int Ed Engl
; 51(44): 11073-8, 2012 Oct 29.
Article
en En
| MEDLINE
| ID: mdl-23038154
ABSTRACT
It all clicks into place A potent telomere-targeting small molecule has been identified by using the copper-free 1,3-dipolar cycloaddition of a series of alkyne and azide building blocks catalyzed by a non-Watson-Crick DNA secondary structure (see picture). This method rapidly identifies, otherwise unanticipated, potent small-molecule probes to selectively target a given RNA or DNA.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Azidas
/
ADN
/
ARN
/
Alquinos
/
G-Cuádruplex
Límite:
Humans
Idioma:
En
Revista:
Angew Chem Int Ed Engl
Año:
2012
Tipo del documento:
Article
País de afiliación:
Reino Unido