Blood alterations preceding clinical manifestation of glioblastoma.
Cancer Invest
; 30(9): 625-9, 2012 Nov.
Article
en En
| MEDLINE
| ID: mdl-23061753
ABSTRACT
BACKGROUND:
There is little knowledge on blood alterations of glioblastoma. We had the opportunity to investigate markers from plasma taken 66, 36, and 6 months before glioblastoma in a patient in the VITA study.METHODS:
We determined S100B, secretagogin, neuropeptide-Y, micro-RNA-21, let-7, micro-RNA-128, and micro-RNA-342-3p in our patient and 10 controls from VITA.RESULTS:
We found a four-fold increase of micro-RNA-21 in the plasma of glioblastoma patient, whereas controls showed a significant decrease. There was no difference in other protein or micro-RNA levels between the patient and controls.CONCLUSION:
Plasma micro-RNA-21 may be associated with glioblastoma development in individual cases.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Neoplasias Encefálicas
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Biomarcadores
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Glioblastoma
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MicroARNs
Límite:
Aged
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Female
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Humans
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Male
Idioma:
En
Revista:
Cancer Invest
Año:
2012
Tipo del documento:
Article
País de afiliación:
Austria