Changes in apparent diffusion coefficient and T2 relaxation during radiotherapy for prostate cancer.
J Magn Reson Imaging
; 37(4): 909-16, 2013 Apr.
Article
en En
| MEDLINE
| ID: mdl-23097411
ABSTRACT
PURPOSE:
To evaluate regional and temporal changes in apparent diffusion coefficient (ADC) and T2 relaxation during radiation therapy (RT) in patients with low and intermediate risk localized prostate cancer. MATERIALS ANDMETHODS:
Seventeen patients enrolled on a prospective clinical trial where MRI was acquired every 2 weeks throughout eight weeks of image-guided prostate IMRT (78 Gy/39 fractions). ADC and T2 quantification used entire prostate, central gland, benign peripheral zone, and tumor-dense regions-of-interest, and mean values were evaluated for common response trends.RESULTS:
Overall, the RT responses were greater than volunteer measurement repeatability, and week 6 appeared to be an optimum time-point for early detection. RT effects on the entire prostate were best detected using ADC (5-7% by week 2, P < 0.0125), effects on peripheral zone were best detected using T2 (19% reduction at week 6; P = 0.004) and effects on tumors were best detected using ADC (14% elevation at week 6; P = 0.004).CONCLUSION:
ADC and T2 may be candidate biomarkers of early response to RT warranting further investigation against clinical outcomes.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Próstata
/
Neoplasias de la Próstata
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Interpretación de Imagen Asistida por Computador
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Aumento de la Imagen
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Imagen de Difusión por Resonancia Magnética
/
Radioterapia de Intensidad Modulada
Tipo de estudio:
Etiology_studies
/
Observational_studies
/
Risk_factors_studies
/
Screening_studies
Límite:
Aged
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
J Magn Reson Imaging
Asunto de la revista:
DIAGNOSTICO POR IMAGEM
Año:
2013
Tipo del documento:
Article
País de afiliación:
Canadá