Quantification of the dynamics of enterovirus 71 infection by experimental-mathematical investigation.
J Virol
; 87(1): 701-5, 2013 Jan.
Article
en En
| MEDLINE
| ID: mdl-23097444
ABSTRACT
Enterovirus 71 (EV71) is the causative agent of hand-foot-and-mouth disease and can trigger neurological disorders. EV71 outbreaks are a major public health concern in Asia-Pacific countries. By performing experimental-mathematical investigation, we demonstrate here that viral productivity and transmissibility but not viral cytotoxicity are drastically different among EV71 strains and can be associated with their epidemiological backgrounds. This is the first report demonstrating the dynamics of nonenveloped virus replication in cell culture using mathematical modeling.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Brotes de Enfermedades
/
Enterovirus Humano A
/
Enfermedad de Boca, Mano y Pie
Límite:
Humans
País/Región como asunto:
Asia
Idioma:
En
Revista:
J Virol
Año:
2013
Tipo del documento:
Article
País de afiliación:
Japón