[Progesterone receptor-mediated molecular mechanisms on mammalian female reproduction].
Yi Chuan
; 34(10): 1223-32, 2012 Oct.
Article
en Zh
| MEDLINE
| ID: mdl-23099778
ABSTRACT
The steroid hormone, progesterone, plays a critical role in regulation of mammalian female reproductive activities. Besides the non-genomic activity of progesterone on target cells, its main physiological effect is caused through genomic action by the ligand-dependent nuclear progesterone receptor. The genomic and non-genomic effects of progesterone collectively mediate various female reproductive functions, including ovulation, embryo implantation, maintenance of pregnancy, initiation of parturition, and development of mammary gland. Although a large number of candidate genes regulated by progesterone have been identified by gene chip technology, the traditional progesterone response elements located in the promoter region of downstream target genes havenot been detected. Accordingly, it was suggested thatthe mechanism of nuclear progesterone receptors regulating transcription may be different from other nuclear steroid receptors. In this review, we summarized the mechanisms of progesterone receptors mediating the physiological effects in various female re-productive activities.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Reproducción
/
Receptores de Progesterona
Límite:
Animals
/
Female
/
Humans
/
Pregnancy
Idioma:
Zh
Revista:
Yi Chuan
Asunto de la revista:
GENETICA
Año:
2012
Tipo del documento:
Article
País de afiliación:
China