Molecular participants in regulation of the meiotic cell cycle in mammalian oocytes.
Reprod Fertil Dev
; 25(3): 484-94, 2013.
Article
en En
| MEDLINE
| ID: mdl-23206331
ABSTRACT
Meiosis in oocytes consists of two consecutive asymmetric cell divisions, each completed by the extrusion of one set of chromosomes into a small polar body. First polar body (PBI) extrusion is triggered by the inactivation of cyclin-dependent kinase 1 (CDK1), following the degradation of its regulatory subunit cyclin B1 by the ubiquitin proteasome pathway. The present review covers the sequence of events leading to PBI extrusion, and compares them to the corresponding events in mitotic cell division. The latest findings regarding the contribution of ubiquitin chain topology, separase, securin, cyclin B1, CDK1, Polo-like kinase 1 and mitogen-activated protein kinase kinase 1/2 to the regulation of meiosis are discussed.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Oocitos
/
Meiosis
Límite:
Animals
/
Female
/
Humans
Idioma:
En
Revista:
Reprod Fertil Dev
Asunto de la revista:
MEDICINA REPRODUTIVA
Año:
2013
Tipo del documento:
Article
País de afiliación:
Israel