Facile synthesis of multicompartment micelles based on biocompatible poly(3-hydroxyalkanoate).
Macromol Rapid Commun
; 34(4): 362-8, 2013 Feb 25.
Article
en En
| MEDLINE
| ID: mdl-23238932
ABSTRACT
In this paper, a straightforward method to produce poly(3-hydroxyalkanoate)-based multicompartment micelles (MCMs) is presented. Thiol-ene addition is used to graft sequentially perfluorooctyl chains and poly(ethylene glycol) oligomers onto poly(3-hydroxyoctanoate-co-hydroxyundecenoate) oligomers backbone. Well-defined copolymers are obtained as shown by ¹H NMR and size-exclusion chromatography. After nanoprecipitation in water, novel PHA-based MCMs are evidenced by cryo-transmission electron microscopy. Moreover, the cytocompatibility of MCMs is demonstrated in vitro via cell viability assay.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Materiales Biocompatibles
/
Polihidroxialcanoatos
/
Micelas
Límite:
Animals
Idioma:
En
Revista:
Macromol Rapid Commun
Año:
2013
Tipo del documento:
Article
País de afiliación:
Francia