Lithium clearance in healthy humans: effects of sodium intake and diuretics.
Kidney Int Suppl
; 28: S36-8, 1990 Mar.
Article
en En
| MEDLINE
| ID: mdl-2325335
ABSTRACT
In summary, our experiments clearly demonstrate that lithium reabsorption occurs by frusemide- and bumetanide-sensitive reabsorption, but we have failed to identify the mechanism(s) responsible for the lower CLi and FELi in salt-depletion. It is possible that some, as yet unknown, factor increases the activity of the Na, K, 2Cl cotransporter and, hence, increases lithium reabsorption in the thick ascending limb in salt-depleted subjects. However, it is equally possible that a fraction of proximal tubular reabsorption is inhibited by frusemide and bumetanide. If this is correct, CLi in humans are reasonable markers of proximal tubular function even in conditions of avid salt retention and in salt depletion, when fractional reabsorption of salt and water in the proximal tubules is enhanced.
Buscar en Google
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Sodio en la Dieta
/
Diuréticos
/
Litio
Tipo de estudio:
Prognostic_studies
Límite:
Humans
Idioma:
En
Revista:
Kidney Int Suppl
Año:
1990
Tipo del documento:
Article
País de afiliación:
Reino Unido