Small-world networks in individuals at ultra-high risk for psychosis and first-episode schizophrenia during a working memory task.
Neurosci Lett
; 535: 35-9, 2013 Feb 22.
Article
en En
| MEDLINE
| ID: mdl-23262086
ABSTRACT
Disturbances of functional interaction between different brain regions have been hypothesized to be the major pathophysiological mechanism underlying the cognitive deficits of schizophrenia. We investigated the small-world functional networks in individuals at ultra-high risk (UHR) for psychosis, first-episode schizophrenia (FESPR) patients, and healthy controls. All participants underwent the electroencephalogram during a control task and a working memory (WM) task. Small-world properties of the theta band were reduced in FESPR relative to controls during the WM task. Small-worldness of the UHR during the WM task exhibited intermediate value between that of controls and FESPR. These results imply that the suboptimal organization of the brain network may play a pivotal role in the schizophrenia pathophysiology.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Trastornos Psicóticos
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Esquizofrenia
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Psicología del Esquizofrénico
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Encéfalo
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Red Nerviosa
Tipo de estudio:
Etiology_studies
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Prognostic_studies
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Risk_factors_studies
Límite:
Adult
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Female
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Humans
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Male
Idioma:
En
Revista:
Neurosci Lett
Año:
2013
Tipo del documento:
Article