Perfluorodecalin and bone regeneration.
Eur Cell Mater
; 25: 22-36, 2013 Jan 02.
Article
en En
| MEDLINE
| ID: mdl-23283637
ABSTRACT
Perfluorodecalin (PFD) is a chemically and biologically inert biomaterial and, as many perfluorocarbons, is also hydrophobic, radiopaque and has a high solute capacity for gases such as oxygen. In this article we have demonstrated, both in vitro and in vivo, that PFD may significantly enhance bone regeneration. Firstly, the potential benefit of PFD was demonstrated by prolonging the survival of bone marrow cells cultured in anaerobic conditions. These findings translated in vivo, where PFD incorporated into bone-marrow-loaded 3D-printed scaffolds substantially improved their capacity to regenerate bone. Secondly, in addition to biological applications, we have also shown that PFD improves the radiopacity of bone regeneration biomaterials, a key feature required for the visualisation of biomaterials during and after surgical implantation. Finally, we have shown how the extreme hydrophobicity of PFD enables the fabrication of highly cohesive self-setting injectable biomaterials for bone regeneration. In conclusion, perfluorocarbons would appear to be highly beneficial additives to a number of regenerative biomaterials, especially those for bone regeneration.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Regeneración Ósea
/
Fosfatos de Calcio
/
Sustitutos de Huesos
/
Fluorocarburos
Tipo de estudio:
Diagnostic_studies
Límite:
Animals
Idioma:
En
Revista:
Eur Cell Mater
Año:
2013
Tipo del documento:
Article
País de afiliación:
Canadá