[Successful treatment using recombinant thrombomodulin for disseminated intravascular coagulation associated with recurrent prosthetic valve endocarditis].
Kyobu Geka
; 66(2): 101-5, 2013 Feb.
Article
en Ja
| MEDLINE
| ID: mdl-23381354
ABSTRACT
Prosthetic valve endocarditis(PVE)occasionally evokes sepsis and disseminated intravascular coagulation(DIC). A 46-year-old man developed relapsing active PVE with an annular abscess and suffered from exacerbating sepsis and DIC. Despite the administration of antibiotics, his DIC score increased. Anti-DIC treatment with recombinant thrombomodulin (rTM) was initiated, and his DIC was remarkably resolved. Accordingly, the abscess cavity was closed by using a homograft anterior mitral leaflet, and the aortic root was replaced with the homograft. He is doing well without an evidence of recurrent endocarditis 18 months after the operation. rTM is a new and promising drug for the treatment of DIC with infective endocarditis.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Prótesis Valvulares Cardíacas
/
Infecciones Relacionadas con Prótesis
/
Trombomodulina
/
Coagulación Intravascular Diseminada
/
Endocarditis
Tipo de estudio:
Risk_factors_studies
Límite:
Humans
/
Male
/
Middle aged
Idioma:
Ja
Revista:
Kyobu Geka
Año:
2013
Tipo del documento:
Article
País de afiliación:
Japón