Vitamin A and retinoid signaling: genomic and nongenomic effects.
J Lipid Res
; 54(7): 1761-75, 2013 Jul.
Article
en En
| MEDLINE
| ID: mdl-23440512
ABSTRACT
Vitamin A or retinol is arguably the most multifunctional vitamin in the human body, as it is essential from embryogenesis to adulthood. The pleiotropic effects of vitamin A are exerted mainly by one active metabolite, all-trans retinoic acid (atRA), which regulates the expression of a battery of target genes through several families of nuclear receptors (RARs, RXRs, and PPARß/δ), polymorphic retinoic acid (RA) response elements, and multiple coregulators. It also involves extranuclear and nontranscriptional effects, such as the activation of kinase cascades, which are integrated in the nucleus via the phosphorylation of several actors of RA signaling. However, vitamin A itself proved recently to be active and RARs to be present in the cytosol to regulate translation and cell plasticity. These new concepts expand the scope of the biologic functions of vitamin A and RA.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Retinoides
/
Vitamina A
/
Transducción de Señal
Límite:
Animals
/
Humans
Idioma:
En
Revista:
J Lipid Res
Año:
2013
Tipo del documento:
Article
País de afiliación:
Francia