Natural aristolactams and aporphine alkaloids as inhibitors of CDK1/cyclin B and DYRK1A.
Molecules
; 18(3): 3018-27, 2013 Mar 06.
Article
en En
| MEDLINE
| ID: mdl-23467012
ABSTRACT
In an effort to find potent inhibitors of the protein kinases DYRK1A and CDK1/Cyclin B, a systematic in vitro evaluation of 2,500 plant extracts from New Caledonia and French Guyana was performed. Some extracts were found to strongly inhibit the activity of these kinases. Four aristolactams and one lignan were purified from the ethyl acetate extracts of Oxandra asbeckii and Goniothalamus dumontetii, and eleven aporphine alkaloids were isolated from the alkaloid extracts of Siparuna pachyantha, S. decipiens, S. guianensis and S. poeppigii. Among these compounds, velutinam, aristolactam AIIIA and medioresinol showed submicromolar IC50 values on DYRK1A.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Aporfinas
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Proteínas Tirosina Quinasas
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Extractos Vegetales
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Proteína Quinasa CDC2
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Proteínas Serina-Treonina Quinasas
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Ciclina B
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Alcaloides Indólicos
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Lactamas
Idioma:
En
Revista:
Molecules
Asunto de la revista:
BIOLOGIA
Año:
2013
Tipo del documento:
Article
País de afiliación:
Francia