Catalytic Asymmetric Synthesis of Highly Substituted Pyrrolizidines.
Chem Sci
; 4(2): 650-654, 2012 Nov 13.
Article
en En
| MEDLINE
| ID: mdl-23565328
ABSTRACT
A catalytic asymmetric double (1,3)-dipolar cycloaddition reaction has been developed. Using a chiral silver catalyst, enantioenriched pyrrolizidines can be prepared in one flask from inexpensive, commercially available starting materials. The pyrrolizidine products contain a variety of substitution patterns and as many as six stereogenic centers.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Idioma:
En
Revista:
Chem Sci
Año:
2012
Tipo del documento:
Article