Reactivation of hepatitis B virus associated with chemotherapy and immunosuppressive agent.
Acta Med Indones
; 45(1): 61-6, 2013 Jan.
Article
en En
| MEDLINE
| ID: mdl-23585411
ABSTRACT
Hepatitis B virus (HBV) reactivation after chemotherapy or immunosuppressive therapy is a serious cause of liver-related morbidity and mortality. The mechanism of HBV reactivation is still unclear, but it is believed due to the suppression of immune response hence increasing the viral load. No uniform diagnostic criteria are available, HBV reactivation can be confirmed by an increase in serum HBV-DNA level. There are many consensus regarding this issue, including the type and duration of nucleoside analogue therapy which need to be understood as not all chronic hepatitis B patients will lead to HBV reactivation. Recently, there has been an increased awareness of reactivation of occult hepatitis B virus, especially in hepatitis B virus endemic area, including Indonesia as part of Asia Pacific region. Preempative antiviral therapy was the best approach to prevent the HBV reactivation.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Activación Viral
/
Virus de la Hepatitis B
/
Inmunosupresores
/
Antineoplásicos
Tipo de estudio:
Risk_factors_studies
Límite:
Humans
Idioma:
En
Revista:
Acta Med Indones
Año:
2013
Tipo del documento:
Article
País de afiliación:
Indonesia