ß-Amyloid (Aß) oligomers impair brain-derived neurotrophic factor retrograde trafficking by down-regulating ubiquitin C-terminal hydrolase, UCH-L1.

Poon, Wayne W; Carlos, Anthony J; Aguilar, Brittany L; Berchtold, Nicole C; Kawano, Crystal K; Zograbyan, Vahe; Yaopruke, Tim; Shelanski, Michael; Cotman, Carl W

Poon, Wayne W; Carlos, Anthony J; Aguilar, Brittany L; Berchtold, Nicole C; Kawano, Crystal K; Zograbyan, Vahe; Yaopruke, Tim; Shelanski, Michael; Cotman, Carl W.

Afiliación

Poon WW; Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, California 92697. Electronic address: wpoon@uci.edu.
Carlos AJ; Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, California 92697.
Aguilar BL; Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, California 92697.
Berchtold NC; Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, California 92697.
Kawano CK; Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, California 92697.
Zograbyan V; Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, California 92697.
Yaopruke T; Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, California 92697.
Shelanski M; Department of Pathology and the Taub Institute, Columbia University, New York, New York 10032.
Cotman CW; Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, California 92697.

J Biol Chem ; 288(23): 16937-16948, 2013 Jun 07.

Article en En | MEDLINE | ID: mdl-23599427

Asunto(s)

Enfermedad de Alzheimer/metabolismo; Péptidos beta-Amiloides/metabolismo; Factor Neurotrófico Derivado del Encéfalo/metabolismo; Hipocampo/metabolismo; Ubiquitina Tiolesterasa/metabolismo; Enfermedad de Alzheimer/genética; Enfermedad de Alzheimer/patología; Péptidos beta-Amiloides/genética; Animales; Factor Neurotrófico Derivado del Encéfalo/genética; Supervivencia Celular/genética; Hipocampo/patología; Humanos; Ratones; Ratones Transgénicos; Plasticidad Neuronal/genética; Neuronas/metabolismo; Neuronas/patología; Transporte de Proteínas/genética; Ratas; Receptor trkB/genética; Receptor trkB/metabolismo; Transducción de Señal/genética; Ubiquitina/genética; Ubiquitina/metabolismo; Ubiquitina Tiolesterasa/genética

Palabras clave

Alzheimer Disease; Amyloid; BDNF; Microfluidic Device; Trafficking; Ubiquitin

Texto completo

Imprimir

XML

PubMed Links

Buscar en Google

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Péptidos beta-Amiloides / Factor Neurotrófico Derivado del Encéfalo / Ubiquitina Tiolesterasa / Enfermedad de Alzheimer / Hipocampo Límite: Animals / Humans Idioma: En Revista: J Biol Chem Año: 2013 Tipo del documento: Article

Texto completo

Imprimir

XML

PubMed Links

Buscar en Google