Genomic analysis of a novel spontaneous albino C57BL/6N mouse strain.

Ryder, Edward; Wong, Kim; Gleeson, Diane; Keane, Thomas M; Sethi, Debarati; Vyas, Sapna; Wardle-Jones, Hannah; Bussell, James N; Houghton, Richard; Salisbury, Jennifer; Harvey, Nina; Adams, David J; Ramirez-Solis, Ramiro

Ryder, Edward; Wong, Kim; Gleeson, Diane; Keane, Thomas M; Sethi, Debarati; Vyas, Sapna; Wardle-Jones, Hannah; Bussell, James N; Houghton, Richard; Salisbury, Jennifer; Harvey, Nina; Adams, David J; Ramirez-Solis, Ramiro.

Afiliación

Ryder E; The Wellcome Trust Sanger Institute, Hinxton, Cambridgeshire CB10 1SA, United Kingdom. er1@sanger.ac.uk

Genesis ; 51(7): 523-8, 2013 Jul.

Article en En | MEDLINE | ID: mdl-23620107

ABSTRACT

ABSTRACT

We report an albino C57BL/6N mouse strain carrying a spontaneous mutation in the tyrosinase gene (C57BL/6N-Tyr(cWTSI)). Deep whole genome sequencing of founder mice revealed very little divergence from C57BL/6NJ and C57BL/6N (Taconic). This coisogenic strain will be of great utility for the International Mouse Phenotyping Consortium (IMPC), which uses the EUCOMM/KOMP targeted C57BL/6N ES cell resource, and other investigators wishing to work on a defined C57BL/6N background.

Asunto(s)

Genoma; Ratones Endogámicos C57BL/genética; Monofenol Monooxigenasa/genética; Análisis de Secuencia de ADN; Albinismo/genética; Animales; Genómica; Genotipo; Ratones; Ratones Transgénicos; Monofenol Monooxigenasa/deficiencia; Monofenol Monooxigenasa/metabolismo

Palabras clave

genetics; genome sequencing; genomics; mammalian; mouse; transgenics

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Genoma / Monofenol Monooxigenasa / Análisis de Secuencia de ADN / Ratones Endogámicos C57BL Límite: Animals Idioma: En Revista: Genesis Asunto de la revista: BIOLOGIA MOLECULAR Año: 2013 Tipo del documento: Article País de afiliación: Reino Unido

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