[Pharmacokinetic effect of Sappan Lignum on hydroxysafflor yellow A in Carthami Flos].
Zhongguo Zhong Yao Za Zhi
; 38(2): 269-72, 2013 Jan.
Article
en Zh
| MEDLINE
| ID: mdl-23672054
ABSTRACT
OBJECTIVE:
To investigate the pharmacokinetic effect of Sappan Lignum on hydroxysafflor yellow A (HSYA) in Carthami Flos.METHOD:
Concentration of HSYA in rat plasma was detected by RP-HPLC after rats were orally administered with extracts of Carthami Flos or Carthami Flos combined with Sappan Lignum. Pharmacokinetic parameters were calculated by DAS 2.0 pharmacokinetic software.RESULT:
In vivo pharmacokinetic models of HSYA were two-compartment open models in both of the Carthami Flos group and the Carthami Flos combined with Sappan Lignum group. After compatibility, HSYA showed a significant lower in apparent volumes of distribution of t(1/2Ka), t(1/2alpha) and V1/F, with slight advance in T(max).CONCLUSION:
Sappan Lignum can accelerate absorption, distribution and metabolic process of HSYA in vivo and reduce its accumulation in vivo.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Quinonas
/
Medicamentos Herbarios Chinos
/
Chalcona
/
Caesalpinia
/
Carthamus tinctorius
Límite:
Animals
Idioma:
Zh
Revista:
Zhongguo Zhong Yao Za Zhi
Asunto de la revista:
FARMACOLOGIA
/
TERAPIAS COMPLEMENTARES
Año:
2013
Tipo del documento:
Article
País de afiliación:
China