Antibiotics acting as neuroprotectants via mechanisms independent of their anti-infective activities.
Neuropharmacology
; 73: 174-82, 2013 Oct.
Article
en En
| MEDLINE
| ID: mdl-23748053
ABSTRACT
This review considers available evidence that some antibiotics have ancillary neuroprotective effects. Notably, ß-lactam antibiotics are believed to increase the expression of glutamate transporter GLT1, potentially relieving the neurological excitotoxicity that characterizes disorders like amyotrophic lateral sclerosis. Minocycline has shown promise in reducing the severity of a number of neurological diseases, including multiple sclerosis, most likely by reducing apoptosis and the expression of inflammatory mediators in the brain. Rapamycin inhibits the activity of a serine/threonine protein kinase that has a role in the pathogenesis of numerous neurologic diseases. Herein we examine the unique neuroprotective aspects of these drugs originally developed as anti-infective agents.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Fármacos Neuroprotectores
/
Antibacterianos
/
Enfermedades del Sistema Nervioso
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Neuropharmacology
Año:
2013
Tipo del documento:
Article
País de afiliación:
Estados Unidos