Human necrotizing vasculitis: immunoglobulins and complement in vessel walls of cutaneous lesions and normal skin.
J Invest Dermatol
; 64(6): 441-5, 1975 Jun.
Article
en En
| MEDLINE
| ID: mdl-237967
ABSTRACT
Immunoglobulins and C3 were detected by immunofluorescence in the blood vessel walls of biopsies of clinically normal skin in patients with active necrotizing vasculitis. Of the 13 patients studied, 9 had C3 and 6 of these had IgM or IgA in biopsies of lesions of vasculitis. In adjacent clinically normal skin, 7 patients had C3 and 3 of these also had IgM or IgA. These findings support the hypothesis that immunoglobulins and complement are present in vessels of some patients prior to chemotaxis of polymorphonuclear leukocytes and the resulting inflammatory purpuric lesions so characteristic of necrotizing vasculitis.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Poliarteritis Nudosa
/
Piel
/
Vasos Sanguíneos
/
Proteínas del Sistema Complemento
/
Inmunoglobulinas
Límite:
Humans
Idioma:
En
Revista:
J Invest Dermatol
Año:
1975
Tipo del documento:
Article