[Modification of doxorubicin action with artificial hyperglycemia]. / Modifikatsiia deistviia doksorubitsina iskusstvennoi giperglikemiei.
Antibiot Khimioter
; 35(4): 34-6, 1990 Apr.
Article
en Ru
| MEDLINE
| ID: mdl-2383143
ABSTRACT
Approximately a 1.6-fold increase in the antitumor action of doxorubicin used in combination with artificial hyperglycemia was shown on mice C57B1/6 with hemocytoblastosis La. Artificial hyperglycemia was found to change the doxorubicin pharmacokinetics in the experimental animals evident from increased in antibiotic half-life to 42.3 min against 26.5 min in the controls, the apparent initial concentration of doxorubicin being increased 1.6 times. Accumulation of doxorubicin in the bone marrow cells of the mice did not change with artificial hyperglycemia. It was suggested that the increase in the therapeutic effect of doxorubicin used in combination with artificial hyperglycemia was associated with changes in drug pharmacokinetics.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Leucemia Experimental
/
Doxorrubicina
/
Leucemia-Linfoma Linfoblástico de Células Precursoras
/
Glucosa
/
Hiperglucemia
Tipo de estudio:
Prognostic_studies
Límite:
Animals
Idioma:
Ru
Revista:
Antibiot Khimioter
Asunto de la revista:
TERAPIA POR MEDICAMENTOS
Año:
1990
Tipo del documento:
Article