The B1-cell subpopulation is diminished in patients with relapsing-remitting multiple sclerosis.
J Neuroimmunol
; 262(1-2): 92-9, 2013 Sep 15.
Article
en En
| MEDLINE
| ID: mdl-23856341
ABSTRACT
B cell subsets in newly diagnosed untreated, relapsing-remitting multiple sclerosis (MS) patients were examined. The fraction of CD20(+) B cells was significantly increased in MS. Among subsets of B cells, MS patients had increased frequency of naïve cells, but reduced frequency of memory and B1 cells. The frequencies of B1 cells were inversely correlated with the time since last attack. B1 cells resembled the phenotype of either lymphocytes (CD11b(-) B1 cells) or monocytes (CD11b(+) B1 cells) and a small fraction of cells was CD3(+)CD20(+) by confocal microscopy.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Regulación hacia Abajo
/
Subgrupos de Linfocitos B
/
Esclerosis Múltiple Recurrente-Remitente
Límite:
Adult
/
Female
/
Humans
/
Male
Idioma:
En
Revista:
J Neuroimmunol
Año:
2013
Tipo del documento:
Article
País de afiliación:
Dinamarca