Caffeic acid phenethyl ester activation of Nrf2 pathway is enhanced under oxidative state: structural analysis and potential as a pathologically targeted therapeutic agent in treatment of colonic inflammation.

Kim, Hyunjeong; Kim, Wooseong; Yum, Soohwan; Hong, Sungchae; Oh, Jeong-Eun; Lee, Ji-Woo; Kwak, Mi-Kyoung; Park, Eun Ji; Na, Dong Hee; Jung, Yunjin

Kim, Hyunjeong; Kim, Wooseong; Yum, Soohwan; Hong, Sungchae; Oh, Jeong-Eun; Lee, Ji-Woo; Kwak, Mi-Kyoung; Park, Eun Ji; Na, Dong Hee; Jung, Yunjin.

Afiliación

Kim H; College of Pharmacy, Pusan National University, Busan 609-735, Republic of Korea.
Kim W; College of Pharmacy, Pusan National University, Busan 609-735, Republic of Korea.
Yum S; College of Pharmacy, Pusan National University, Busan 609-735, Republic of Korea.
Hong S; College of Pharmacy, Pusan National University, Busan 609-735, Republic of Korea.
Oh JE; Department of Civil and Environmental Engineering, Pusan National University, Busan 609-735, Republic of Korea.
Lee JW; Department of Civil and Environmental Engineering, Pusan National University, Busan 609-735, Republic of Korea.
Kwak MK; College of Pharmacy, The Catholic University of Korea, Bucheon, Gyeonggi-do 420-743, Republic of Korea.
Park EJ; College of Pharmacy, Kyungpook National University, Daegu, 702-701, Republic of Korea.
Na DH; College of Pharmacy, Kyungpook National University, Daegu, 702-701, Republic of Korea.
Jung Y; College of Pharmacy, Pusan National University, Busan 609-735, Republic of Korea. Electronic address: jungy@pusan.ac.kr.

Free Radic Biol Med ; 65: 552-562, 2013 Dec.

Article en En | MEDLINE | ID: mdl-23892357

Asunto(s)

Antiinflamatorios/farmacología; Ácidos Cafeicos/farmacología; Colitis/metabolismo; Factor 2 Relacionado con NF-E2/metabolismo; Alcohol Feniletílico/análogos & derivados; Transducción de Señal/efectos de los fármacos; Animales; Antiinflamatorios/química; Western Blotting; Ácidos Cafeicos/química; Línea Celular Tumoral; Cromatografía Líquida de Alta Presión; Modelos Animales de Enfermedad; Ensayo de Inmunoadsorción Enzimática; Humanos; Inmunoprecipitación; Estrés Oxidativo/efectos de los fármacos; Alcohol Feniletílico/química; Alcohol Feniletílico/farmacología; Ratas; Reacción en Cadena de la Polimerasa de Transcriptasa Inversa; Relación Estructura-Actividad

Palabras clave

2,4,6-Trinitrobenzene sulfonic acid; 3-phenylpropionic acid phenethyl ester; ARE; Antioxidant response element; BTCA; BTDHHC; BTDMC; Biotin-tagged caffeic acid; Biotin-tagged dihydroxydihydrocinnamic acid; Biotin-tagged dimethoxycinnamic acid; CAPE; Caffeic acid phenethyl ester; DHHC; DMC; DMHC; Dihydrohydroxycinnamic acid phenethyl ester; Dimethoxycinnamic acid phenethyl ester; Dimethoxydihydrocinnamic acid phenethyl ester; Electrophile; HBSS; Hank's buffered salt solution; Keap1; Kelch-like ECH associated protein 1; MPO; Nrf2; Nuclear factor-erythroid 2 p45 (NF-E2)-related factor 2; Oxidation of catechol; PPAPE; Pathologically targeted therapeutic agent; Structural analysis; TNBS; myeloperoxidase

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Alcohol Feniletílico / Ácidos Cafeicos / Transducción de Señal / Colitis / Factor 2 Relacionado con NF-E2 / Antiinflamatorios Tipo de estudio: Prognostic_studies Límite: Animals / Humans Idioma: En Revista: Free Radic Biol Med Asunto de la revista: BIOQUIMICA / MEDICINA Año: 2013 Tipo del documento: Article

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