Expanded polyglutamine-containing N-terminal huntingtin fragments are entirely degraded by mammalian proteasomes.

Juenemann, Katrin; Schipper-Krom, Sabine; Wiemhoefer, Anne; Kloss, Alexander; Sanz Sanz, Alicia; Reits, Eric A J

Juenemann, Katrin; Schipper-Krom, Sabine; Wiemhoefer, Anne; Kloss, Alexander; Sanz Sanz, Alicia; Reits, Eric A J.

Afiliación

Juenemann K; Department of Cellbiology and Histology, Academic Medical Center, University of Amsterdam, Meibergdreef 15, 1105 AZ Amsterdam, The Netherlands. Electronic address: k.junemann@amc.uva.nl.
Schipper-Krom S; Department of Cellbiology and Histology, Academic Medical Center, University of Amsterdam, Meibergdreef 15, 1105 AZ Amsterdam, The Netherlands.
Wiemhoefer A; Department of Cellbiology and Histology, Academic Medical Center, University of Amsterdam, Meibergdreef 15, 1105 AZ Amsterdam, The Netherlands.
Kloss A; Institut für Biochemie/CCM, Charité-Universitätsmedizin Berlin, Monbijoustrasse 2, Berlin 10117, Germany.
Sanz Sanz A; Department of Cellbiology and Histology, Academic Medical Center, University of Amsterdam, Meibergdreef 15, 1105 AZ Amsterdam, The Netherlands.
Reits EAJ; Department of Cellbiology and Histology, Academic Medical Center, University of Amsterdam, Meibergdreef 15, 1105 AZ Amsterdam, The Netherlands. Electronic address: e.a.reits@amc.uva.nl.

J Biol Chem ; 288(38): 27068-27084, 2013 Sep 20.

Article en En | MEDLINE | ID: mdl-23908352

Asunto(s)

Proteínas del Tejido Nervioso/metabolismo; Proteínas Nucleares/metabolismo; Péptidos/metabolismo; Complejo de la Endopetidasa Proteasomal/metabolismo; Proteolisis; Animales; Línea Celular; Humanos; Proteína Huntingtina; Ratones; Ratones Noqueados; Proteínas del Tejido Nervioso/genética; Proteínas Nucleares/genética; Péptidos/genética; Complejo de la Endopetidasa Proteasomal/genética; Secuencias Repetitivas de Aminoácido

Palabras clave

Aggregation; Autophagy; Huntington Disease; Polyglutamine; Proteasome

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Péptidos / Proteínas Nucleares / Complejo de la Endopetidasa Proteasomal / Proteolisis / Proteínas del Tejido Nervioso Límite: Animals / Humans Idioma: En Revista: J Biol Chem Año: 2013 Tipo del documento: Article

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