Phospholipid-modified polyethylenimine-based nanopreparations for siRNA-mediated gene silencing: implications for transfection and the role of lipid components.

Navarro, Gemma; Essex, Sean; Sawant, Rupa R; Biswas, Swati; Nagesha, Dattatri; Sridhar, Srinivas; de ILarduya, Conchita Tros; Torchilin, Vladimir P

Navarro, Gemma; Essex, Sean; Sawant, Rupa R; Biswas, Swati; Nagesha, Dattatri; Sridhar, Srinivas; de ILarduya, Conchita Tros; Torchilin, Vladimir P.

Afiliación

Navarro G; Center for Pharmaceutical Biotechnology and Nanomedicine, Northeastern University, Boston, MA, USA.
Essex S; Center for Pharmaceutical Biotechnology and Nanomedicine, Northeastern University, Boston, MA, USA.
Sawant RR; Center for Pharmaceutical Biotechnology and Nanomedicine, Northeastern University, Boston, MA, USA.
Biswas S; Department of Pharmacy, Birla Institute of Technology and Sciences-Pilani., Hyderabad Campus Jawahar Nagar, Shameerpet Mandal. Hyderabad-500078. AP., India.
Nagesha D; Department of Pharmaceutics, JSS College of Pharmacy, JSS University S. S. Nagar, Mysore 570 015.
Sridhar S; Electronic Materials Research Institute, Northeastern University, Boston, MA, USA.
de ILarduya CT; Department of Pharmacy and Pharmaceutical Technology, School of Pharmacy, University of Navarra, Pamplona, Spain.
Torchilin VP; Center for Pharmaceutical Biotechnology and Nanomedicine, Northeastern University, Boston, MA, USA. Electronic address: v.torchilin@neu.edu.

Nanomedicine ; 10(2): 411-9, 2014 Feb.

Article en En | MEDLINE | ID: mdl-23928214

Asunto(s)

Lípidos/química; Nanopartículas/química; Fosfolípidos/química; Polietileneimina/química; Interferencia de ARN; Animales; Línea Celular; Membrana Celular/metabolismo; Portadores de Fármacos/química; Etanolaminas/química; Proteínas Fluorescentes Verdes/metabolismo; Humanos; Concentración 50 Inhibidora; Ratones; Micelas; Peso Molecular; Nanomedicina; Fosforilcolina/química; ARN Interferente Pequeño/química

Palabras clave

Lipid conjugation; Micelle; Phospholipid; Polyethylenimine; RNA interference; siRNA delivery

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Fosfolípidos / Polietileneimina / Interferencia de ARN / Nanopartículas / Lípidos Límite: Animals / Humans Idioma: En Revista: Nanomedicine Asunto de la revista: BIOTECNOLOGIA Año: 2014 Tipo del documento: Article País de afiliación: Estados Unidos

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