Beyond the histone tail: acetylation at the nucleosome dyad commands transcription.
Nucleus
; 4(5): 343-8, 2013.
Article
en En
| MEDLINE
| ID: mdl-23941995
ABSTRACT
Post-translational modifications (PTMs) of histones have been implicated in cellular processes such as transcription, replication and DNA repair. These processes normally involve dynamic changes in chromatin structure and DNA accessibility. Most of the PTMs reported so far map on the histone tails and essentially affect chromatin structure indirectly by recruiting effector proteins. A recent study by Schneider and colleagues published in Cell (1) has uncovered the function of H3K122 acetylation found within the histone globular domain and specifically positioned on the DNA-bound surface of the nucleosome. Their findings demonstrate a direct effect of histone PTMs on chromatin dynamics, and propose that modifications located in different parts of the nucleosome employ distinct regulatory mechanisms.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Histonas
/
Activación Transcripcional
/
Regulación de la Expresión Génica
/
Código de Histonas
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Nucleus
Año:
2013
Tipo del documento:
Article
País de afiliación:
Chipre