Downregulation of ERp57 expression is associated with poor prognosis in early-stage cervical cancer.
Biomarkers
; 18(7): 573-9, 2013 Nov.
Article
en En
| MEDLINE
| ID: mdl-23957851
ABSTRACT
OBJECTIVE:
We investigated the clinical significance of ERp57 in the progression of cervical cancer.METHODS:
mRNA and protein expression of ERp57 in cervical neoplasias were examined.RESULTS:
ERp57 mRNA expression was significantly decreased in cervical cancers. Immunohistochemistry revealed that ERp57 expression in 123 cervical cancers was down-regulated compared to cervical intraepithelial neoplasias or normal tissues (p < 0.001). Low ERp57 expression was significantly associated with worse overall survival (HR = 12.19, p = 0.018).CONCLUSIONS:
Low ERp57 expression independently predicts a poor outcome for patients with cervical cancer, supporting the notion that ERp57 may be a promising novel cancer target.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Expresión Génica
/
Displasia del Cuello del Útero
/
Neoplasias del Cuello Uterino
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Proteína Disulfuro Isomerasas
Tipo de estudio:
Prognostic_studies
/
Risk_factors_studies
Límite:
Adult
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Aged
/
Female
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Humans
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Middle aged
Idioma:
En
Revista:
Biomarkers
Asunto de la revista:
BIOQUIMICA
Año:
2013
Tipo del documento:
Article
País de afiliación:
Estados Unidos