The intrahepatic signalling niche of hedgehog is defined by primary cilia positive cells during chronic liver injury.

Grzelak, Candice Alexandra; Martelotto, Luciano Gastón; Sigglekow, Nicholas David; Patkunanathan, Bramilla; Ajami, Katerina; Calabro, Sarah Ruth; Dwyer, Benjamin James; Tirnitz-Parker, Janina Elke Eleonore; Watkins, D Neil; Warner, Fiona Jane; Shackel, Nicholas Adam; McCaughan, Geoffrey William

Grzelak, Candice Alexandra; Martelotto, Luciano Gastón; Sigglekow, Nicholas David; Patkunanathan, Bramilla; Ajami, Katerina; Calabro, Sarah Ruth; Dwyer, Benjamin James; Tirnitz-Parker, Janina Elke Eleonore; Watkins, D Neil; Warner, Fiona Jane; Shackel, Nicholas Adam; McCaughan, Geoffrey William.

Afiliación

Grzelak CA; Liver Injury and Cancer, Centenary Institute, Camperdown, NSW, Australia.
Martelotto LG; Centre for Cancer Research, Monash Institute of Medical Research, Monash University, Clayton, VIC, Australia; Department of Pathology, Memorial Sloan-Kettering Cancer Center, New York, NY, USA.
Sigglekow ND; Liver Injury and Cancer, Centenary Institute, Camperdown, NSW, Australia.
Patkunanathan B; Liver Injury and Cancer, Centenary Institute, Camperdown, NSW, Australia.
Ajami K; Liver Injury and Cancer, Centenary Institute, Camperdown, NSW, Australia.
Calabro SR; Liver Injury and Cancer, Centenary Institute, Camperdown, NSW, Australia.
Dwyer BJ; School of Biomedical Sciences, Curtin Health Innovation Research Institute, Curtin University, Bentley, WA, Australia.
Tirnitz-Parker JE; School of Biomedical Sciences, Curtin Health Innovation Research Institute, Curtin University, Bentley, WA, Australia.
Watkins DN; Centre for Cancer Research, Monash Institute of Medical Research, Monash University, Clayton, VIC, Australia.
Warner FJ; Liver Injury and Cancer, Centenary Institute, Camperdown, NSW, Australia.
Shackel NA; Liver Injury and Cancer, Centenary Institute, Camperdown, NSW, Australia; A. W. Morrow Gastroenterology and Liver Centre, R.P.A.H., Camperdown, NSW, Australia; Faculty of Medicine, University of Sydney, Sydney, NSW, Australia.
McCaughan GW; Liver Injury and Cancer, Centenary Institute, Camperdown, NSW, Australia; A. W. Morrow Gastroenterology and Liver Centre, R.P.A.H., Camperdown, NSW, Australia; Faculty of Medicine, University of Sydney, Sydney, NSW, Australia. Electronic address: g.mccaughan@centenary.org.au.

J Hepatol ; 60(1): 143-51, 2014 Jan.

Article en En | MEDLINE | ID: mdl-23978713

Asunto(s)

Enfermedad Hepática Inducida por Sustancias y Drogas/patología; Cilios/fisiología; Proteínas Hedgehog/fisiología; Hígado/patología; Transducción de Señal/fisiología; Animales; Enfermedad Crónica; Transición Epitelial-Mesenquimal; Factores de Transcripción de Tipo Kruppel/análisis; Factores de Transcripción de Tipo Kruppel/fisiología; Masculino; Ratones; Ratones Endogámicos C57BL; Proteínas Nucleares/análisis; Receptores Acoplados a Proteínas G/fisiología; Receptor Smoothened; Tioacetamida; Proteína con Dedos de Zinc GLI1; Proteína Gli2 con Dedos de Zinc

Palabras clave

ALD; ALT; CK; DHH; Desert Hedgehog; EGF; EMT; EpCAM; GLI; GLI cleaved repressor; GLI full-length activator; GLI-A; GLI-Kruppel family of transcription factors; GLI-R; HGF; HSC; Hedgehog; Hedgehog signalling pathway; Hh; IHH; Indian Hedgehog; LPC; Liver progenitor cells; MCDE; N-Hh; N-terminal Hedgehog signalling peptide; NT2; Non-canonical cell signalling; PTCH1; Patched 1; Pc; Primary cilia; Ptc1(+/−); Ptc1-lacZ reporter; SHH; SMO; Smoothened; Sonic Hedgehog; TAA; Thioacetamide; alanine aminotransferase; alcoholic liver disease; cytokeratin; epidermal growth factor; epithelial cell adhesion molecule; epithelial-to-mesenchymal transition; hepatic stellate cell; hepatocyte growth factor; liver progenitor cell; methionine choline-deficient diet+ethionine; non-targeting control; primary cilia; thioacetamide; α-SMA; α-smooth muscle actin

Texto completo

Imprimir

XML

PubMed Links

Buscar en Google

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Transducción de Señal / Cilios / Proteínas Hedgehog / Enfermedad Hepática Inducida por Sustancias y Drogas / Hígado Límite: Animals Idioma: En Revista: J Hepatol Asunto de la revista: GASTROENTEROLOGIA Año: 2014 Tipo del documento: Article País de afiliación: Australia

Texto completo

Imprimir

XML

PubMed Links

Buscar en Google