Epidithiodiketopiperazine biosynthesis: a four-enzyme cascade converts glutathione conjugates into transannular disulfide bridges.
Angew Chem Int Ed Engl
; 52(42): 11092-5, 2013 Oct 11.
Article
en En
| MEDLINE
| ID: mdl-24039048
ABSTRACT
Enzyme quartet Isolation of the first sulfur-bearing intermediate of the gliotoxin pathway in Aspergillus fumigatus and successful inâ
vitro conversion of the bisglutathione adduct into an intact epidithiodiketopiperazine by a four-enzyme cascade (including glutamyltransferase GliK and dipeptidase GliJ) revealed an outstanding adaptation of a primary metabolic pathway into natural product biosynthesis that is widespread in fungi.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Piperazinas
/
Aspergillus fumigatus
/
Disulfuros
/
Glutatión
Idioma:
En
Revista:
Angew Chem Int Ed Engl
Año:
2013
Tipo del documento:
Article