FOXO in the hole: leveraging GWAS for outcome and function.
Cell
; 155(1): 11-2, 2013 Sep 26.
Article
en En
| MEDLINE
| ID: mdl-24074853
ABSTRACT
GWAS studies of autoimmune disorders have yielded hundreds of replicated associations, but moving from genetic association to functional studies with potential clinical relevance is a challenge. Leveraging GWAS data, Lee et al. now identify FOXO3 activity as predictive of disease severity in Crohn's disease and rheumatoid arthritis as well as malaria, likely by acting through regulation of cytokine production in monocytes.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Artritis Reumatoide
/
Enfermedad de Crohn
/
Malaria Falciparum
/
Polimorfismo de Nucleótido Simple
/
Factores de Transcripción Forkhead
Tipo de estudio:
Prognostic_studies
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Cell
Año:
2013
Tipo del documento:
Article