Synthesis of methoxy-X04 derivatives and their evaluation in Alzheimer's disease pathology.
Neurodegener Dis
; 13(4): 209-13, 2014.
Article
en En
| MEDLINE
| ID: mdl-24080522
ABSTRACT
BACKGROUND:
Alzheimer's disease is characterized by two notorious protein aggregates in the brain extracellular senile plaques mainly consisting of amyloid-ß peptides and tau-protein-derived intracellular paired helical filaments. The diagnosis of Alzheimer's disease is impaired by insufficient sensitivity and specificity of diagnostic methods to visualize these pathological hallmarks over all disease stages.OBJECTIVE:
The established fluorescence marker methoxy-X04 stains plaques, tau tangles and amyloid-derived angiopathies with good specificity, yet it is limited by slow elimination in vivo. Since the need for new markers is high, we prepared methoxy-X04 derivatives and evaluated their potential as imaging agents in Alzheimer's disease pathology. METHODS ANDRESULTS:
In this study, we describe an improved synthesis for methoxy-X04 and its derivatives and their affinity determination for the respective protein targets by immunohistology and a displacement assay.CONCLUSION:
This resulted in the identification of new derivatives of methoxy-X04 with improved binding affinity.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Derivados del Benceno
/
Alquenos
/
Enfermedad de Alzheimer
Límite:
Humans
Idioma:
En
Revista:
Neurodegener Dis
Asunto de la revista:
NEUROLOGIA
Año:
2014
Tipo del documento:
Article
País de afiliación:
Alemania