Antineoplásicos/farmacología; Agonismo Inverso de Drogas; Receptor Cannabinoide CB1/agonistas; Receptor Cannabinoide CB2/agonistas; Moduladores Selectivos de los Receptores de Estrógeno/farmacología; Tamoxifeno/análogos & derivados; Tamoxifeno/farmacología; Animales; Antineoplásicos/química; Células CHO; Membrana Celular/química; Cricetulus; Humanos; Ratones; Unión Proteica; Receptor Cannabinoide CB1/química; Receptor Cannabinoide CB2/química; Moduladores Selectivos de los Receptores de Estrógeno/química; Tamoxifeno/química

4OH-Tam; 4OH-Tamoxifen; 5-(1,1-dimethylheptyl)-2-[5-hydroxy-2-(3-hydroxypropyl)cyclohexyl]phenol; AC; Antagonist; CB1R; CB2R; CHO; CP-55,940; Cannabinoid receptors; Cannabinoids; Chinese hamster ovary; DMEM; Drug action; Drug discovery; Dulbecco's modification of Eagle's medium; ER; G-protein coupled receptor; G-protein coupled receptors; GPCR; IBMX; Inverse agonist; SERM; Tam; Tamoxifen; WIN-55,212-2; [(35)S]GTPγS; [(3R)-2,3-dihydro-5-methyl-3-(4-morpholinylmethyl)pyrrolo[1,2,3-de]-1,4-benzoxazin-6-yl]-1-naphthalenyl-methanone; adenylyl cyclase; cannabinoid receptor type 1; cannabinoid receptor type 2; estrogen receptor; guanosine 5'-O-(3-[(35)S]thio)triphosphate; hCB2; hMOR; human CB2 receptors; human mu-opioid receptors; isobutyl-methyl-xanthine; selective estrogen receptor modulator