Absence of detectable HIV-1 viremia after treatment cessation in an infant.
N Engl J Med
; 369(19): 1828-35, 2013 Nov 07.
Article
en En
| MEDLINE
| ID: mdl-24152233
ABSTRACT
An infant born to a woman with human immunodeficiency virus type 1 (HIV-1) infection began receiving antiretroviral therapy (ART) 30 hours after birth owing to high-risk exposure. ART was continued when detection of HIV-1 DNA and RNA on repeat testing met the standard diagnostic criteria for infection. After therapy was discontinued (when the child was 18 months of age), levels of plasma HIV-1 RNA, proviral DNA in peripheral-blood mononuclear cells, and HIV-1 antibodies, as assessed by means of clinical assays, remained undetectable in the child through 30 months of age. This case suggests that very early ART in infants may alter the establishment and long-term persistence of HIV-1 infection.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Viremia
/
ARN Viral
/
Infecciones por VIH
/
VIH-1
/
Antirretrovirales
Tipo de estudio:
Diagnostic_studies
Límite:
Child, preschool
/
Humans
/
Male
Idioma:
En
Revista:
N Engl J Med
Año:
2013
Tipo del documento:
Article