Wild type and mutant amyloid precursor proteins influence downstream effects of proteasome and autophagy inhibition.

Cecarini, Valentina; Bonfili, Laura; Cuccioloni, Massimiliano; Mozzicafreddo, Matteo; Rossi, Giacomo; Keller, Jeffrey N; Angeletti, Mauro; Eleuteri, Anna Maria

Cecarini, Valentina; Bonfili, Laura; Cuccioloni, Massimiliano; Mozzicafreddo, Matteo; Rossi, Giacomo; Keller, Jeffrey N; Angeletti, Mauro; Eleuteri, Anna Maria.

Afiliación

Cecarini V; School of Biosciences and Biotechnology, University of Camerino, 62032 Camerino, Italy. Electronic address: valentina.cecarini@unicam.it.
Bonfili L; School of Biosciences and Biotechnology, University of Camerino, 62032 Camerino, Italy.
Cuccioloni M; School of Biosciences and Biotechnology, University of Camerino, 62032 Camerino, Italy.
Mozzicafreddo M; School of Biosciences and Biotechnology, University of Camerino, 62032 Camerino, Italy.
Rossi G; School of Medical Veterinary Sciences, University of Camerino, 62024 Matelica, Italy.
Keller JN; Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, LA, USA.
Angeletti M; School of Biosciences and Biotechnology, University of Camerino, 62032 Camerino, Italy.
Eleuteri AM; School of Biosciences and Biotechnology, University of Camerino, 62032 Camerino, Italy.

Biochim Biophys Acta ; 1842(2): 127-34, 2014 Feb.

Article en En | MEDLINE | ID: mdl-24215712

Asunto(s)

Precursor de Proteína beta-Amiloide/metabolismo; Autofagia/fisiología; Proteínas Mutantes/metabolismo; Complejo de la Endopetidasa Proteasomal/metabolismo; Adenina/análogos & derivados; Adenina/farmacología; Sustitución de Aminoácidos; Precursor de Proteína beta-Amiloide/genética; Autofagia/efectos de los fármacos; Western Blotting; Catepsina B/metabolismo; Línea Celular Tumoral; Supervivencia Celular/efectos de los fármacos; Inhibidores de Cisteína Proteinasa/farmacología; Humanos; Inmunohistoquímica; Leupeptinas/farmacología; Proteínas Mutantes/genética; Mutación; Proteolisis/efectos de los fármacos

Palabras clave

3-methyladenine; 3MA; AP-N; APP; Amyloid precursor protein; Autophagy; Aß; BrAAP; Cathepsin B; ChT-L; IHC; PGPH; T-L; UPS; Ubiquitinproteasome system; aminopeptidase N; amyloid precursor protein; amyloid-ß; branched-chain amino acids preferring; chymotrypsin-like; immunohistochemistry; peptidylglutamyl-peptide hydrolyzing; trypsin-like; ubiquitinproteasome system

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Autofagia / Precursor de Proteína beta-Amiloide / Complejo de la Endopetidasa Proteasomal / Proteínas Mutantes Límite: Humans Idioma: En Revista: Biochim Biophys Acta Año: 2014 Tipo del documento: Article

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